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Stem cells for the treatment of urinary incontinence.

Andrea A Staack and Larissa V LV Rodríguez

Audio, Transactions of the IRE Professional... 12(1):41-6 (2011) PMID 21113694

Stress urinary incontinence (SUI) is highly prevalent. As of now, there is no minimally invasive long-term treatment available. Adult stem cells are nonimmunogenic and have the ability to self-renew and to differentiate into multiple cell types. Over the past decade, in vivo studies have described periurethral injections of adult-derived stem cells for the treatment of SUI. The ultimate goal has been to achieve a permanent cure for SUI by restoration of the intrinsic and extrinsic urethral sphincter and the surrounding connective tissue, including peripheral nerves and blood vessels. For this purpose, future studies need to focus on delivery systems, cell survival, and functional improvement of the urethral closure mechanism, including improvement of innervation and vascularization.

DOI: 10.1007/s11934-010-0155-z
Version: za2963e q8za3 q8zb8 q8zc0 q8zd1 q8ze6 q8zf3 q8zg7
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