Advanced search×

Advances in the diagnosis and management of central venous access device infections in children.

Asha A Bowen and Jonathan J Carapetis

Adv Exp Med Biol (2011) PMID 21120722

Infection is a well-known complication of central venous access device (CVAD) use, with an incidence of 3-6 bloodstream infections per 1,000 catheter days in children. Prevention of CVAD infections has improved with new strategies including the use of chlorhexidine antisepsis, bundles, maximal sterile barriers for insertion, prophylactic locks, antibiotic impregnated catheters and tunnelling of long-term devices. Despite these strategies, catheter-related bloodstream infections (CRBSIs) continue to be an important health problem. New approaches to diagnosis include differential time to positivity and quantification of blood cultures and molecular diagnostics. The management of CRBSIs includes techniques for line salvage including ethanol, antibiotic, hydrochloric acid, taurolidine and urokinase locks. When these fail, line removal and antimicrobial therapy are recommended.

DOI: 10.1007/978-1-4419-7185-2_8
Version: za2963e q8za6 q8zbd q8zcd q8zd9 q8zec q8zf0 q8zgb
Buy PDF

Similar articles you may find interesting…

  1. Mechanistic insight into human ether-à-go-go-related gene (hERG) K+ channel deactivation gating from the solution structure of the EAG domai...
    Frederick W FW Muskett, Samrat S Thouta, ... John S JS Mitcheson

    J Biol Chem 286(8):6184-91 (2011) PMID 21135103

    We present an NMR structure for the entire eag domain, which reveals that NT1-26 is structurally independent from the PAS domain and contains a stable amphipathic helix with one face being positively charged. Mutagenesis and electrophysiological studies indicate that neutralising basic residues and...
    PDF not found
  2. Pneumatosis intestinalis in non-neonatal pediatric patients.
    A C Kurbegov and J M Sondheimer

    Pediatrics 108(2):402-6 (2001) PMID 11483806

    PI is a radiologic sign that occurs in a variety of settings in non-neonates. PI preceded by bowel ischemia or graft versus host disease colitis has the worst prognosis, and the presence of portal venous gas and acidosis correlate with poor outcome. Not all patients with pneumoperitoneum require sur...
    Buy PDF
  3. Preliminary results of a phase I trial of prophylactic ethanol-lock administration to prevent mediport catheter-related bloodstream infectio...
    Mark L Kayton, Edward G Garmey, ... Michael P La Quaglia

    J Pediatr Surg 45(10):6 (2010) PMID 20920713

    Although children with mediport catheters exhibited nontoxic blood ethanol levels and a low rate of bloodstream infections following prophylactic ethanol-lock use, there was a high incidence of catheter occlusion. Adjustments are necessary before adopting ethanol-locks for routine prophylaxis agains...
    Buy PDF