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Impaired brain creatine kinase activity in Huntington's disease.

S F SF Zhang, T T Hennessey, L L Yang, N N NN Starkova, M F MF Beal, and A A AA Starkov

Neurodegener Dis 8(4):194-201 (2011) PMID 21124007 PMCID PMC3214941

Huntington's disease (HD) is associated with impaired energy metabolism in the brain. Creatine kinase (CK) catalyzes ATP-dependent phosphorylation of creatine (Cr) into phosphocreatine (PCr), thereby serving as readily available high-capacity spatial and temporal ATP buffering.

DOI: 10.1159/000321681
Version: za2963e q8za8 q8zbe q8zc4 q8zdd q8ze2 q8zf4 q8zg7
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