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The ghrelin O-acyltransferase-ghrelin system: a novel regulator of glucose metabolism.

Kristy M KM Heppner, Jenny J Tong, Henriette H Kirchner, Ralf R Nass, and Matthias H MH Tschöp

Curr Opin Endocrinol Diabetes Obes 18(1):50-5 (2011) PMID 21150588

Ghrelin, an orexigenic hormone secreted from the stomach, exists in the circulation in two isoforms: des-acyl and acyl ghrelin. Acylation by the enzyme ghrelin O-acyl-transferase (GOAT) enables ghrelin to activate the ghrelin receptor. This review discusses recent findings illustrating the role of acyl ghrelin, des-acyl ghrelin and GOAT in regulating glucose homeostasis.

DOI: 10.1097/MED.0b013e328341e1d3
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