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Hyaluronan esters drive Smad gene expression and signaling enhancing cardiogenesis in mouse embryonic and human mesenchymal stem cells.

Margherita Maioli, Sara Santaniello, Andrea Montella, Pasquale Bandiera, Silvia Cantoni, Claudia Cavallini, Francesca Bianchi, Vincenzo Lionetti, Flavio Rizzolio, Irene Marchesi, Luigi Bagella, and Carlo Ventura

PLoS One 5(11):e15151 (2010) PMID 21152044

Development of molecules chemically modifying the expression of crucial orchestrator(s) of stem cell commitment may have significant biomedical impact. We have recently developed hyaluronan mixed esters of butyric and retinoic acids (HBR), turning cardiovascular stem cell fate into a high-yield process. The HBR mechanism(s) remain still largely undefined.

DOI: 10.1371/journal.pone.0015151
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