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Mechanism of inactivation of influenza viruses by immobilized hydrophobic polycations.

Bryan B Hsu, Sze Yinn Wong, Paula T Hammond, Jianzhu Chen, and Alexander M Klibanov

Proc Natl Acad Sci U S A 108(1):61-6 (2011) PMID 21173278 PMCID PMC3017173

N,N-dodecyl,methyl-polyethylenimine coatings applied to solid surfaces have been shown by us to disinfect aqueous solutions of influenza viruses. Herein we elucidate the mechanism of this phenomenon. Infectivity-, protein-, RNA-, and scanning electron microscopy-based experiments reveal that, upon contact with the hydrophobic polycationic coating, influenza viruses (including pathogenic human and avian, both wild-type and drug-resistant, strains) irreversibly adhere to it, followed by structural damage and inactivation; subsequently, viral RNA is released into solution, while proteins remain adsorbed.

DOI: 10.1073/pnas.1017012108
Version: za2963e q8za9 q8zb7 q8zcf q8zd9 q8zed q8zfc q8zg0
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