Advanced search×

Oxytocin and carbetocin ameliorating effects on restraint stress-induced short- and long-term behavioral changes in rats.

Vera V Klenerova, Ivan I Krejci, Pavel P Sida, Zdenek Z Hlinak, and Sixtus S Hynie

Neuro Endocrinol Lett 31(5):622-30 (2010) PMID 21173744

Carbetocin (CBT), an oxytocin (OXY) analog, was designed to exert prolonged peripheral actions. It has also been proposed as potential therapeutic mean in certain psychiatric disorders where OXY role has been implicated. This study examined the effects of both peptides on behavior of naive and restraint stress exposed rats in the open field (OF) and elevated plus maze (EPM) tests.

Version: za2963e q8zad q8zb1 q8zc8 q8zdb q8ze0 q8zfa q8zg6

Similar articles you may find interesting…

  1. Dynamics of immediate early gene and neuropeptide gene response to prolonged immobilization stress: evidence against a critical role of the ...
    Lenka L Trnecková, David D Rotllant, ... Antonio A Armario

    J Neurochem 100(4):905-14 (2007) PMID 17217423

    We studied in selected telencephalic, diencephalic and brainstem regions the mRNA levels of two clearly distinct IEGs (c-fos and arc) during prolonged exposure to a severe stressor such as immobilization (IMO) and after releasing the rats from the situation. Although regional differences were observ...
  2. Modulary effects of oxytocin and carbetocin on stress-induced changes in rat behavior in the open-field.
    V Klenerova, I Krejci, ... S Hynie

    J Physiol Pharmacol 60(2):57-62 (2009) PMID 19617646

    We investigated the impact of these peptides on the behavioral changes in rats exposed repeatedly to restraint stressors. Wistar male rats were exposed to restraint for 1 hour; saline or drugs were administered intraperitoneally immediately after stress termination. Recording of the exploratory acti...
    PDF not found
  3. Retinal pigment epithelial cells synthesize laminins, including laminin 5, and adhere to them through alpha3- and alpha6-containing integrin...
    Sabine S Aisenbrey, Minlei M Zhang, ... Dale D DD Hunter

    Invest Ophthalmol Vis Sci 47(12):5537-44 (2006) PMID 17122146

    Retinal diseases are often accompanied by changes in the structure of the multilayered extracellular matrix underlying the retina, Bruch's membrane (BrM). These structural revisions potentially lead to alterations in retinal pigment epithelium (RPE) adhesion, likely via modification of interactions w...