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Cell-specific aptamer-mediated targeted drug delivery.

Jiehua Zhou and John J Rossi

Oligonucleotides 21(1):1-10 (2011) PMID 21182455

Nucleic acid aptamers are in vitro-selected small, single-stranded DNA or RNA oligonucleotides that can specifically recognize their target on the basis of their unique 3-dimensional structures. Recent advances in the development of escort aptamers to deliver and enhance the efficacy of other therapeutic agents have drawn enthusiasm in exploiting cell-type-specific aptamers as drug delivery vehicles. This review mainly focuses on the recent developments of aptamer-mediated targeted delivery systems. We also place particular emphasis on aptamers evolved against cell membrane receptors and possibilities for translation to clinical applications.

DOI: 10.1089/oli.2010.0264
Version: za2963e q8zab q8zb1 q8zc0 q8zd8 q8zea q8zf6 q8zg4
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