In recent years, the podocyte, with its elaborate cytoarchitecture and slit diaphragm, has been the focus of extensive research, yet its precise role in the glomerular filtration barrier is still debated. There are puzzling observations indicating that a comprehensive mechanistic model for glomerular filtration is still necessary. There is no doubt that podocytes are essential for glomerular filtration barrier integrity. However, most albumin never reaches the podocyte because it is prevented from entering the glomerular filter at the endothelium level. Another puzzling observation is that the glomerular filter never clogs despite its high load of several kilograms of plasma proteins per day. Recently, we proposed a novel model in which an electrical potential difference is generated across the glomerular filtration barrier by filtration. The model offers novel potential solutions to some of the riddles regarding the glomerular filter.
Clarify an inaccurate understanding which claims that no spectroscopic
Information can be extracted from N-S point-contacts showing conductance dips
At finite bias. Such a clarification of the origin of conductance dips in AR
Spectra is important for future research in this field....
We present a new parallel implementation of the PINpointing Orbit
Crossing-Collapsed HIerarchical Objects (PINOCCHIO) algorithm, a quick tool,
Based on Lagrangian Perturbation Theory, for the hierarchical build-up of Dark
Matter halos in cosmological volumes. To assess its ability to predict halo
We report the first single crystal growth of this material.
Through physical property measurements, scattering experiments, and theoretical
Modelling, we offer novel insight into the Y2Mo2O7 problem: for this
Unconventional spin glass, orbital effects should not be ignored....
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