Advanced search×

The safety and efficacy of EGFR TKIs monotherapy versus single-agent chemotherapy using third-generation cytotoxics as the first-line treatment for patients with advanced non-small cell lung cancer and poor performance status.

Shan S Liu, Deqiang D Wang, Bo B Chen, Yan Y Wang, Weihong W Zhao, and Jianqing J Wu

Lung Cancer 73(2):203-10 (2011) PMID 21211862

To assess the risk/benefit profiles of EGFR TKIs monotherapy using erlotinib or gefitinib in comparison with single-agent chemotherapy using third-generation cytotoxics (gemcitabine, vinorelbine, taxanes) as the first-line treatment for chemonaÏve patients with advanced non-small cell lung cancer (ANSCLC) and poor performance status (PS).

Copyright © 2011 Elsevier Ltd. All rights reserved.

DOI: 10.1016/j.lungcan.2010.12.006
Version: za2963e q8zaf q8zbc q8zce q8zd2 q8ze4 q8zfa q8zg8

Similar articles you may find interesting…

  1. The effect of stimulus frequency on the analgesic response to percutaneous electrical nerve stimulation in patients with chronic low back pa...
    E S ES Ghoname, W F WF Craig, ... C E CE Noe

    Anesth Analg 88(4):841-6 (1999) PMID 10195535

    We designed this sham-controlled study to compare the effect of three different frequencies of electrical stimulation on the analgesic response to PENS therapy. Sixty-eight consenting patients with LBP secondary to degenerative lumbar disc disease were treated with PENS therapy at 4 Hz, alternating...
  2. Analgesic efficacy and safety of tramadol/ acetaminophen combination tablets (Ultracet) in treatment of chronic low back pain: a multicenter...
    Paul M PM Peloso, Luc L Fortin, ...

    Journal Watch (General) 31(12):2454-63 (2004) PMID 15570651

    In total, 336 intent-to-treat patients received tramadol/APAP (n = 167) or placebo (n = 169). Mean baseline pain VAS score was 67.8. Intent-to-treat analysis showed significantly better mean final pain VAS scores (47.4 vs 62.9; p < 0.001) and mean final pain relief scores (1.8 vs 0.7; p < 0.001) for...
  3. Adequacy assessment of oxycodone/paracetamol (acetaminophen) in multimodal chronic pain : a prospective observational study.
    Antonio Gatti, Alessandro Fabrizio Sabato, ... Roberto Occhioni

    Clin Drug Investig (2009) PMID 19445553

    Multimodal pain is comprised of nociceptive/inflammatory and neuropathic components. Pharmacological pain therapies from different classes provide pain relief using different mechanistic actions; often a combination of such therapies provides more effective pain relief than monothera...