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The role of serotonin in the NMDA receptor antagonist models of psychosis and cognitive impairment.

Herbert Y Meltzer, Masakuni Horiguchi, and Bill W Massey

Psychopharmacology (Berl) 213(2-3):289-305 (2011) PMID 21212939

To review the evidence that agents which preferentially affect serotonin (5-HT) attenuate the ability of N-methyl-D-aspartate (NMDA) receptor non-competitive antagonists (NMDA-RA), e.g., phencyclidine (PCP), dizocilpine (MK-801), and ketamine, to stimulate locomotor activity (LA), and to impair novel object recognition (NOR).

DOI: 10.1007/s00213-010-2137-8
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