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The inflammasome NLRs in immunity, inflammation, and associated diseases.

Beckley K BK Davis, Haitao H Wen, and Jenny P-Y JP Ting

Immunology (2011) PMID 21219188

Inflammasome activation leads to caspase-1 activation, which causes the maturation and secretion of pro-IL-1β and pro-IL-18 among other substrates. A subgroup of the NLR (nucleotide-binding domain, leucine-rich repeat containing) proteins are key mediators of the inflammasome. Studies of gene-deficient mice and cells have implicated NLR inflammasomes in a host of responses to a wide range of microbial pathogens, inflammatory diseases, cancer, and metabolic and autoimmune disorders. Determining exactly how the inflammasome is activated in these diseases and disease models remains a challenge. This review presents and integrates recent progress in the field.

DOI: 10.1146/annurev-immunol-031210-101405
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