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Divergent responses to peptidoglycans derived from different E. coli serotypes influence inflammatory outcome in trout, Oncorhynchus mykiss, macrophages

Sebastian Boltaña, Felipe Reyes-Lopez, Davinia Morera, Frederick Goetz, and Simon A MacKenzie

BMC Genomics 12(1):34 (2011) PMID 21235753

Pathogen-associated molecular patterns (PAMPs) are structural components of pathogens such as lipopolysaccharide (LPS) and peptidoglycan (PGN) from bacterial cell walls. PAMP-recognition by the host results in an induction of defence-related genes and often the generation of an inflammatory response. We evaluated both the transcriptomic and inflammatory response in trout (O. mykiss) macrophages in primary cell culture stimulated with DAP-PGN (DAP; meso-diaminopimelic acid, PGN; peptidoglycan) from two strains of Escherichia coli (PGN-K12 and PGN-O111:B4) over time.

DOI: 10.1186/1471-2164-12-34
Version: za2963e q8zab q8zbe q8zce q8zd9 q8ze3 q8zf1 q8zga
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