Advanced search×

Divergent responses to peptidoglycans derived from different E. coli serotypes influence inflammatory outcome in trout, Oncorhynchus mykiss, macrophages

Sebastian Boltaña, Felipe Reyes-Lopez, Davinia Morera, Frederick Goetz, and Simon A MacKenzie

BMC Genomics 12(1):34 (2011) PMID 21235753

Pathogen-associated molecular patterns (PAMPs) are structural components of pathogens such as lipopolysaccharide (LPS) and peptidoglycan (PGN) from bacterial cell walls. PAMP-recognition by the host results in an induction of defence-related genes and often the generation of an inflammatory response. We evaluated both the transcriptomic and inflammatory response in trout (O. mykiss) macrophages in primary cell culture stimulated with DAP-PGN (DAP; meso-diaminopimelic acid, PGN; peptidoglycan) from two strains of Escherichia coli (PGN-K12 and PGN-O111:B4) over time.

DOI: 10.1186/1471-2164-12-34
Version: za2963e q8zab q8zbe q8zce q8zd9 q8ze3 q8zf1 q8zga
PDF not found

Similar articles you may find interesting…

  1. Nationwide cross-sectional population-based study on the prevalences of asthma and asthma symptoms among Japanese adults.
    Yuma Fukutomi, Hiroyuki Nakamura, ... Kazuo Akiyama

    Int Arch Allergy Immunol 153(3):280-7 (2010) PMID 20484927

    This nationwide study determined the prevalences of asthma and asthma symptoms among Japanese adults. The results provide fundamental information on the respiratory health of Japanese adults. Copyright © 2010 S. Karger AG, Basel....
    Buy PDF
  2. [Reversal of pulmonary hypertrophic osteoarthropathy in surgically treated lung cancer].
    Yasuka Y Hara, Yoshifumi Y Matsuura, ... Yuji Y Matsumura

    Nihon Kokyuki Gakkai Zasshi 48(12):966-71 (2010) PMID 21226306

    A 61-year-old man was admitted for evaluation of an abnormal chest abnormal with progressive swelling in both hands, clubbing of all fingers and toes, and polyarthroceles. He was given a diagnosis of pulmonary hypertrophic osteoarthropathy (PHO) associated with primary lung cancer, and underwent an...
    Buy PDF
  3. Aryl hydrocarbon receptor ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin enhances liver damage in bile duct-ligated mice
    Jun Ozeki, Shigeyuki Uno, ... Makoto Makishima

    Toxicology 280(1-2):8 (2011) PMID 21095216

    We investigated the effects of AHR activation under conditions of cholestasis. We administered oral TCDD to mice at a dose that can effectively induce Cyp1 gene expression without overt liver toxicity and then ligated their bile ducts. TCDD pretreatment enhanced bile duct ligation (BDL)-induced incr...
    View PDF