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Follow-up Survey of Children Who Received Sulfadoxine-Pyrimethamine for Intermittent Preventive Antimalarial Treatment in Infants.

Robin Kobbe, Benedikt Hogan, Samuel Adjei, Philipp Klein, Benno Kreuels, Wibke Loag, Ohene Adjei, and Jürgen May

J Infect Dis 203(4):556-60 (2011) PMID 21248056

Recently, the World Health Organization emphasized the potential benefit of intermittent preventive treatment in infants (IPTi) to control malaria and officially recommended implementation of IPTi with sulfadoxine-pyrimethamine (SP) in areas with moderate and high transmission, where SP resistance is not high. As reported rebound effects make further observation mandatory, we performed a survey of participants of a former IPTi trial. Malariometric parameters were similar in the SP and the placebo group. In contrast, anti-Plasmodium falciparum lysate immunoglobulin G antibody levels, a proxy measure for preceding malaria episodes, remained lower in the SP arm. The most likely explanation is a lower overall exposure to parasitic antigens after IPTi.

DOI: 10.1093/infdis/jiq079
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