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Hyperglycemia activates caspase-1 and TXNIP-mediated IL-1beta transcription in human adipose tissue.

Tim B TB Koenen, Rinke R Stienstra, Lambertus J LJ van Tits, Jacqueline J de Graaf, Anton F H AF Stalenhoef, Leo A B LA Joosten, Cees J CJ Tack, and Mihai G MG Netea

Diabetes 60(2):517-24 (2011) PMID 21270263

Obesity is characterized by elevated levels of proinflammatory cytokines, including interleukin (IL)-1β, that contribute to the development of insulin resistance. In this study, we set out to investigate whether hyperglycemia drives IL-1β production and caspase-1 activation in murine and human adipose tissue, thus inducing insulin resistance.

DOI: 10.2337/db10-0266
Version: za2963e q8za5 q8zbc q8zc3 q8zd8 q8zec q8zf1 q8zgc
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