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Neolamarckines A and B, new indole alkaloids from Neolamarckia cadamba.

Ahmad Kaleem AK Qureshi, Mat Ropi MR Mukhtar, Yusuke Y Hirasawa, Takahiro T Hosoya, Alfarius Eko AE Nugroho, Hiroshi H Morita, Osamu O Shirota, Khalit K Mohamad, A Hamid A AH Hadi, Marc M Litaudon, and Khalijah K Awang

Chem Pharm Bull (Tokyo) 59(2):291-3 (2011) PMID 21297315

Two new indole alkaloids, neolamarckines A and B (1, 2) were isolated from the leaves of Neolamarckia cadamba (Rubiaceae). Structural elucidation of 1 and 2 was performed by combination of 2D-NMR and circular dichroism (CD) spectra, and chemical correlations. Neolamarckine A (1) showed inhibition of inducible nitric oxide synthase (iNOS) dose dependently.

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