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Serotonin transporter (SERT) and translocator protein (TSPO) expression in the obese ob/ob mouse.

Gino Giannaccini, Laura Betti, Lionella Palego, Andrea Pirone, Lara Schmid, Mario Lanza, Laura Fabbrini, Caterina Pelosini, Margherita Maffei, Ferruccio Santini, Aldo Pinchera, and Antonio Lucacchini

BMC Neurosci (2011) PMID 21299850

An ever growing body of evidences is emerging concerning metabolism hormones, neurotransmitters or stress-related biomarkers as effective modulators of eating behavior and body weight in mammals. The present study sought at examining the density and affinity of two proteins related to neurotransmission and cell metabolism, the serotonin transporter SERT and the cholesterol import-benzodiazepine site TSPO (translocator protein), in a rodent leptin-lacking mutant, the obese ob/ob mouse. Binding studies were thus carried out in brain or peripheral tissues, blood platelets (SERT) and kidneys (TSPO), of ob/ob and WT mice supplied with a standard diet, using the selective radiochemical ligands [3H]-paroxetine and [3H]-PK11195.

DOI: 10.1186/1471-2202-12-18
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