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Loss of guanylyl cyclase C (GCC) signaling leads to dysfunctional intestinal barrier.

Xiaonan X Han, Elizabeth E Mann, Shila S Gilbert, Yanfang Y Guan, Kris A KA Steinbrecher, Marshall H MH Montrose, and Mitchell B MB Cohen

PLoS One 6(1):e16139 (2011) PMID 21305056

Guanylyl Cyclase C (GCC) signaling via uroguanylin (UGN) and guanylin activation is a critical mediator of intestinal fluid homeostasis, intestinal cell proliferation/apoptosis, and tumorigenesis. As a mechanism for some of these effects, we hypothesized that GCC signaling mediates regulation of intestinal barrier function.

DOI: 10.1371/journal.pone.0016139
Version: za2963e q8za0 q8zb2 q8zc5 q8zde q8ze5 q8zf4 q8zg8
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