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The crystal structure of SDR-type pyridoxal 4-dehydrogenase of Mesorhizobium loti.

Huy Nhat Chu, Jun Kobayashi, Bunzo Mikami, and Toshiharu Yagi

Biosci Biotechnol Biochem 75(2):388-90 (2011) PMID 21307574

Pyridoxal 4-dehydrogenase catalyzes the irreversible oxidation of pyridoxal to 4-pyridoxolactone and is involved in degradation pathway I of pyridoxine, a vitamin B(6) compound. Its crystal structure was elucidated for the first time. Molecular replacement with (S)-1-phenylthanol dehydrogenase (PDB code 2EW8) was adopted to determine the tertiary structure of the NAD(+)-bound enzyme.

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