Advanced search×

Measurements of tumor cell autophagy predict invasiveness, resistance to chemotherapy, and survival in melanoma.

Xiao-Hong XH Ma, Shengfu S Piao, Dan D Wang, Quentin W QW McAfee, Katherine L KL Nathanson, Julian J JJ Lum, Lin Z LZ Li, and Ravi K RK Amaravadi

Clin Cancer Res 17(10):3478-89 (2011) PMID 21325076 PMCID PMC3096713

Autophagy consists of lysosome-dependent degradation of cytoplasmic contents sequestered by autophagic vesicles (AV). The role of autophagy in determining tumor aggressiveness and response to therapy in melanoma was investigated in this study.

DOI: 10.1158/1078-0432.CCR-10-2372
Version: za2963e q8za1 q8zba q8zc1 q8zd3 q8ze1 q8zfc q8zg8
View PDF

Similar articles you may find interesting…

  1. Chemokine networks and breast cancer metastasis.
    Karnoub AE and Weinberg RA

    Breast Dis (2006) PMID 17473367

    We review the current knowledge regarding chemokine/chemokine receptor involvement in breast cancer pathogenesis with primary emphases on their role in the metastatic spread of cancer cells and in tumor-stroma interactions....
  2. Mammalian sirtuins--emerging roles in physiology, aging, and calorie restriction.
    Marcia C MC Haigis and Leonard P LP Guarente

    Genes Dev 20(21):2913-21 (2006) PMID 17079682

    We review recent findings demonstrating the role of these mammalian sirtuins as regulators of physiology, calorie restriction, and aging. The current findings sharpen our understanding of sirtuins as potential pharmacological targets to treat the major diseases of aging....
  3. Ribonuclease inhibitor: structure and function.
    Kimberly A KA Dickson, Marcia C MC Haigis, and Ronald T RT Raines

    Prog Nucleic Acid Res Mol Biol (2005) PMID 16164979

    View PDF