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High dose atorvastatin decreases cellular markers of immune activation without affecting HIV-1 RNA levels: results of a double-blind randomized placebo controlled clinical trial.

Anuradha A Ganesan, Nancy N Crum-Cianflone, Jeanette J Higgins, Jing J Qin, Catherine C Rehm, Julia J Metcalf, Carolyn C Brandt, Jean J Vita, Catherine F CF Decker, Peter P Sklar, Mary M Bavaro, Sybil S Tasker, Dean D Follmann, and Frank F Maldarelli

J Infect Dis 203(6):756-64 (2011) PMID 21325137 PMCID PMC3071124

3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibitors (statins) exhibit antiviral activity against human immunodeficiency virus type 1 (HIV-1) in vitro and may modulate the immune response to HIV infection. Studies evaluating the antiviral activity of statins have yielded conflicting results.

DOI: 10.1093/infdis/jiq115
Version: za2963e q8zab q8zb4 q8zc7 q8zda q8ze2 q8zf7 q8zg6

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