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Opposing oncogenic activities of small DNA tumor virus transforming proteins

G G Chinnadurai

Trends Microbiol 19(4):10 (2011) PMID 21330137

The E1A gene of species C human adenovirus is an intensely investigated model viral oncogene that immortalizes primary cells and mediates oncogenic cell transformation in cooperation with other viral or cellular oncogenes. Investigations using E1A proteins have illuminated important paradigms in cell proliferation and about the functions of cellular proteins such as the retinoblastoma protein. Studies with E1A have led to the unexpected discovery that E1A also suppresses cell transformation and oncogenesis. Here, I review our current understanding of the transforming and tumor-suppressive functions of E1A, and how E1A studies led to the discovery of a related tumor-suppressive function in benign human papillomaviruses. The potential role of these opposing functions in viral replication in epithelial cells is also discussed.

Copyright © 2011 Elsevier Ltd. All rights reserved.

DOI: 10.1016/j.tim.2011.01.003
Version: za2963e q8za5 q8zb1 q8zc2 q8zd6 q8zef q8zf9 q8zg3
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