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Schizophrenia susceptibility alleles are enriched for alleles that affect gene expression in adult human brain.

A L AL Richards, L L Jones, V V Moskvina, G G Kirov, P V PV Gejman, D F DF Levinson, A R AR Sanders, , , S S Purcell, P M PM Visscher, N N Craddock, M J MJ Owen, P P Holmans, and M C MC O'Donovan

Mol Psychiatry 17(2):193-201 (2012) PMID 21339752

It is widely thought that alleles that influence susceptibility to common diseases, including schizophrenia, will frequently do so through effects on gene expression. As only a small proportion of the genetic variance for schizophrenia has been attributed to specific loci, this remains an unproven hypothesis. The International Schizophrenia Consortium (ISC) recently reported a substantial polygenic contribution to that disorder, and that schizophrenia risk alleles are enriched among single-nucleotide polymorphisms (SNPs) selected for marginal evidence for association (P

DOI: 10.1038/mp.2011.11
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