Advanced search×

Schizophrenia susceptibility alleles are enriched for alleles that affect gene expression in adult human brain.

A L AL Richards, L L Jones, V V Moskvina, G G Kirov, P V PV Gejman, D F DF Levinson, A R AR Sanders, , , S S Purcell, P M PM Visscher, N N Craddock, M J MJ Owen, P P Holmans, and M C MC O'Donovan

Mol Psychiatry 17(2):193-201 (2012) PMID 21339752

It is widely thought that alleles that influence susceptibility to common diseases, including schizophrenia, will frequently do so through effects on gene expression. As only a small proportion of the genetic variance for schizophrenia has been attributed to specific loci, this remains an unproven hypothesis. The International Schizophrenia Consortium (ISC) recently reported a substantial polygenic contribution to that disorder, and that schizophrenia risk alleles are enriched among single-nucleotide polymorphisms (SNPs) selected for marginal evidence for association (P

DOI: 10.1038/mp.2011.11
Version: za2963e q8za4 q8zb6 q8zc3 q8zdc q8ze3 q8zf7 q8zge
Buy PDF

Similar articles you may find interesting…

  1. CYP2A6 deletion polymorphism is associated with decreased susceptibility of lung cancer in Asian smokers: a meta-analysis.
    Yu-Liang Liu, Yu Xu, and Shu-Liang Guo

    Tumour Biol (2013) PMID 23649654

    Cytochrome P450 2A6 (CYP2A6) is an enzyme involved in the metabolism of some tobacco carcinogens, which is an important risk factor of lung cancer. Among CYP2A6 allelic variants, CYP2A6*4 presents a whole gene deletion that accounts for the majority of poor metabolizer. In this study...
    Buy PDF
  2. Cost minimization of HLA-B*1502 screening before prescribing carbamazepine in Thailand.
    Somsak Tiamkao, Jukrapope Jitpimolmard, and Suthipun Jitpimolmard

    Int J Clin Pharm (2013) PMID 23649893

    Background Carbamazepine (CBZ) is broadly used for the treatment of epilepsy, neuropathic pain and other neurological diseases, owing to its effectiveness and low price. CBZ can induce Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). There are several studies that...
    Buy PDF
  3. A novel c.-274C>G polymorphism in bovine SIRT1 gene contributes to diminished promoter activity and is associated with increased body size.
    Ming-Xun Li, Xiao-Mei Sun, and Hong Chen

    Anim Genet (2013) PMID 23647079

    We screened and identified a novel polymorphism (c.-274C>G) in the SIRT1 promoter region. In silico prediction reveals that this SNP is in the core of cell cycle-dependent element (CDE)-binding motif. Interestingly, the G allele abolished a CDE-binding site, which suggested its functional significan...
    Buy PDF