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Effect of different iodine nutrition on cerebellum Pcp-2 in rat offspring during lactation.

Lu L Zhang, Yi Na YN Sun, Yong Mei YM Li, Lai Xiang LX Lin, Yan Y Ye, Yu Qin YQ Yan, and Zu Pei ZP Chen

Biol Trace Elem Res 143(3):1629-39 (2011) PMID 21344292

The thyroid functions of breastfed infants, as well as (indirectly) the development of their central nervous system, are dependent on the iodine status of the lactating mother. Purkinje cell protein-2 is a cell-specific marker of the cerebellum Purkinje cell and is a suitable indicator for observing the postnatal development of the cerebellum after birth. We measured the Purkinje cell protein-2 mRNA and protein levels in the rat cerebellum in the critical postnatal (14 days after birth) and maturation periods (28 days after birth) to determine the effect of different nutritional iodine levels on cerebellum growth in the offspring during lactation. We found that severe iodine deficiency resulted in thyroid dysfunction in lactating rats and their offspring on both 14 and 28 days, showing maternal total T(4) 16.7 ± 12.0 vs 36.4 ± 15.0, P 

DOI: 10.1007/s12011-011-8991-3
Version: za2963e q8zac q8zb1 q8zc2 q8zd4 q8zee q8zf5 q8zgb

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