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Enhanced safety profiles of the telomerase-specific replication-competent adenovirus by incorporation of normal cell-specific microRNA-targeted sequences.

Kumiko K Sugio, Fuminori F Sakurai, Kazufumi K Katayama, Katsuhisa K Tashiro, Hayato H Matsui, Kenji K Kawabata, Atsushi A Kawase, Masahiro M Iwaki, Takao T Hayakawa, Toshiyoshi T Fujiwara, and Hiroyuki H Mizuguchi

Clin Cancer Res 17(9):2807-18 (2011) PMID 21346145

Oncolytic adenoviruses (Ad) have been actively pursued as potential agents for cancer treatment. Among the various types of oncolytic Ads, the telomerase-specific replication-competent Ad (TRAD), which possesses an E1 gene expression cassette driven by the human telomerase reverse transcriptase promoter, has shown promising results in human clinical trials; however, the E1 gene is also slightly expressed in normal cells, leading to replication of TRAD and cellular toxicity in normal cells.

DOI: 10.1158/1078-0432.CCR-10-2008
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