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Combining rosuvastatin with sartans of different peroxisome proliferator-activated receptor-γ activating capacity is not associated with different changes in low-density lipoprotein subfractions and plasma lipoprotein-associated phospholipase A₂.

Christos V CV Rizos, Evangelos N EN Liberopoulos, Constantinos C CC Tellis, Matilda M Florentin, Moses S MS Elisaf, and Alexandros D AD Tselepis

Metab Syndr Relat Disord 9(3):217-23 (2011) PMID 21352079

Rosuvastatin reduces low-density lipoprotein cholesterol (LDL-C) and plasma lipoprotein-associated phospholipase A₂ (Lp-PLA₂) Some sartans partially activate peroxisome proliferator-activated receptor-γ (PPARγ), possibly having a favorable effect on metabolic parameters. Telmisartan is the most potent partial PPARγ activator, followed by irbesartan, whereas olmesartan does not hold such capacity. In an open-label randomized study, we assessed the effects of combining sartans of different PPARγ- activating capacity with rosuvastatin on LDL subfractions and plasma Lp-PLA₂ in patients with mixed dyslipidemia, hypertension, and prediabetes.

DOI: 10.1089/met.2010.0120
Version: za2963e q8za9 q8zb9 q8zcf q8zd9 q8zef q8zfe q8zga
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