Advanced search×

Acidosis and alkalosis impair brain functions through weakening spike encoding at cortical GABAergic neurons

Rongrong Song, Liming Zhang, Zichao Yang, and Xiaoyan Tian

J Neurol Sci 304(1-2):5 (2011) PMID 21353681

Acidosis and alkalosis, associated with metabolic disorders, lead to the pathological changes of cognition and behaviors in clinical practices of neurology and psychology. Cellular mechanisms for these functional disorders in the central nervous system remain unclear. We have investigated the influences of acidosis and alkalosis on the functions of cortical GABAergic neurons. Both acidosis and alkalosis impair the ability of encoding sequential spikes at these GABAergic neurons. The impairments of their spiking are associated with the increases of refractory periods, threshold potential and afterhyperpolarization. Our studies reveal that acidosis and alkalosis impair cortical GABAergic neurons and in turn deteriorate brain functions, in which their final targets may be voltage-gated channels of sodium and potassium.

Copyright © 2011 Elsevier Ltd. All rights reserved.

DOI: 10.1016/j.jns.2011.01.024
Version: za2963e q8zac q8zb6 q8zc5 q8zd5 q8zec q8zf8 q8zg1
Buy PDF

Similar articles you may find interesting…

  1. Effect of induced ruminal acidosis on blood variables in heifers.
    Giorgio Marchesini, Roberta De Nardi, and Severino Segato

    BMC Vet Res 9(1):98 (2013) PMID 23647881

    Although additional studies are necessary to confirm the reliability of these discriminant functions, the use of plasma variables in a multifactorial model appeared to be useful for the evaluation of ruminal acidosis severity....
    PDF not found
  2. Cognitive effects of deep brain stimulation for essential tremor: evaluation at 1 and 6 years.
    Ines A Heber, Volker A Coenen, and Martin Kronenbuerger

    J Neural Transm (2013) PMID 23649123

    We examined nine ET patients before surgery (PRE-SURGERY), and 1 and 6 years thereafter with DBS switched on (DBS-ON) and off (DBS-OFF). Standardized neuropsychological tests and reaction time tests were applied. There were no differences in tasks of verbal fluency, memory, and executive and intell...
    Buy PDF
  3. The exaggerated glucagon-like peptide-1 response is important for the improved β-cell function and glucose tolerance after Roux-en-Y gastric...
    Nils B Jørgensen, Carsten Dirksen, and Jens J Holst

    Diabetes (2013) PMID 23649520

    β-cell function is improved in patients with type 2 diabetes in response to an oral glucose stimulus after Roux-en-Y gastric bypass (RYGB) surgery. This has been linked to an exaggerated glucagon-like peptide 1 (GLP-1) secretion, but causality has not been established. The aim of th...
    Buy PDF