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Acidosis and alkalosis impair brain functions through weakening spike encoding at cortical GABAergic neurons.

Rongrong Song, Liming Zhang, Zichao Yang, and Xiaoyan Tian

J Neurol Sci 304(1-2):122-6 (2011) PMID 21353681

Acidosis and alkalosis, associated with metabolic disorders, lead to the pathological changes of cognition and behaviors in clinical practices of neurology and psychology. Cellular mechanisms for these functional disorders in the central nervous system remain unclear. We have investigated the influences of acidosis and alkalosis on the functions of cortical GABAergic neurons. Both acidosis and alkalosis impair the ability of encoding sequential spikes at these GABAergic neurons. The impairments of their spiking are associated with the increases of refractory periods, threshold potential and afterhyperpolarization. Our studies reveal that acidosis and alkalosis impair cortical GABAergic neurons and in turn deteriorate brain functions, in which their final targets may be voltage-gated channels of sodium and potassium. Copyright © 2011 Elsevier B.V. All rights reserved.

Copyright © 2011 Elsevier Ltd. All rights reserved.

DOI: 10.1016/j.jns.2011.01.024
Version: za2963e q8zac q8zb6 q8zc5 q8zd5 q8zec q8zf8 q8zg1

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