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Expression of c-jun is not mandatory for mouse hepatocyte proliferation induced by two nuclear receptor ligands: TCPOBOP and T3.

Vera P VP Leoni, Giovanna M GM Ledda-Columbano, Monica M Pibiri, Christian C Saliba, Andrea A Perra, Marta A MA Kowalik, Oli M V OM Grober, Maria M Ravo, Alessandro A Weisz, Joseph J Locker, Elena E Ghiso, Silvia S Giordano, and Amedeo A Columbano

els 55(5):1069-78 1 Nov 2011 PMID 21354444

Mice lacking c-jun in the liver display impaired regeneration after partial hepatectomy (PH), and were reported to be more resistant to chemically-induced hepatocellular carcinoma (HCC). We investigated the role of c-jun in normal and preneoplastic hepatocyte proliferation induced by ligands of nuclear receptors, which cause liver hyperplasia in the absence of cell loss/death.

DOI: 10.1016/j.jhep.2011.02.016
Version: za2963e q8za5 q8zb4 q8zc8 q8zd2 q8zee q8zfb q8zgb

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