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Toll-like receptor (TLR) 2 promoter and intron 2 polymorphisms are associated with increased risk for spontaneous bacterial peritonitis in liver cirrhosis.

H D HD Nischalke, C C Berger, K K Aldenhoff, L L Thyssen, M M Gentemann, F F Grünhage, F F Lammert, J J Nattermann, T T Sauerbruch, U U Spengler, and B B Appenrodt

els 55(5):1010-6 1 Nov 2011 PMID 21356257

Toll-like receptor (TLR) 2 and nucleotide-binding oligomerisation domain (NOD) 2 recognize distinct pathogen-associated molecular patterns (PAMS) on the cell surface and in the cytoplasm, respectively. Since they may contribute to susceptibility to spontaneous bacterial peritonitis (SBP), we studied the effects of TLR2 gene variants on susceptibility for SBP in relation to the previously reported NOD2 alleles.

DOI: 10.1016/j.jhep.2011.02.022
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