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Genotype-environment interactions in microsatellite stable/microsatellite instability-low colorectal cancer: results from a genome-wide association study.

Jane C JC Figueiredo, Juan Pablo JP Lewinger, Chi C Song, Peter T PT Campbell, David V DV Conti, Christopher K CK Edlund, Dave J DJ Duggan, Jagadish J Rangrej, Mathieu M Lemire, Thomas T Hudson, Brent B Zanke, Michelle M Cotterchio, Steven S Gallinger, Mark M Jenkins, John J Hopper, Robert R Haile, Polly P Newcomb, John J Potter, John A JA Baron, Loic L Le Marchand, and Graham G Casey

Cancer Epidemiol Biomarkers Prev 20(5):758-66 (2011) PMID 21357381 PMCID PMC3089660

Genome-wide association studies (GWAS) have led to the identification of a number of common susceptibility loci for colorectal cancer (CRC); however, none of these GWAS have considered gene-environment (G × E) interactions. Therefore, it is unclear whether current hits are modified by environmental exposures or whether there are additional hits whose effects are dependent on environmental exposures.

DOI: 10.1158/1055-9965.EPI-10-0675
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