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Changes in 18F-fluorodeoxyglucose and 18F-fluorodeoxythymidine positron emission tomography imaging in patients with non-small cell lung cancer treated with erlotinib.

Linda L Mileshkin, Rodney J RJ Hicks, Brett G M BG Hughes, Paul L R PL Mitchell, Veena V Charu, Barbara J BJ Gitlitz, David D Macfarlane, Benjamin B Solomon, Lukas C LC Amler, Wei W Yu, Andrea A Pirzkall, and Bernard M BM Fine

Clin Cancer Res 17(10):3304-15 (2011) PMID 21364032

Assessing clinical activity of molecularly targeted anticancer agents, especially in the absence of tumor shrinkage, is challenging. To evaluate on-treatment 18F-fluorodeoxyglucose (FDG) and/or 18F-fluorodeoxythymidine (FLT) positron emission tomography (PET) for this purpose, we conducted a prospective multicenter trial assessing PET response rates and associations with progression-free (PFS) and overall survival (OS) in 2nd/3rd-line non-small-cell lung cancer patients treated with erlotinib.

DOI: 10.1158/1078-0432.CCR-10-2763
Version: za2963e q8zad q8zb8 q8zcd q8zd3 q8zeb q8zf7 q8zg6

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