Decreasing Incidence and Severity of Cerebral Palsy in Prematurely Born Children
Objective: To examine incidence and severity of cerebral palsy (CP), and associated factors among preterm survivors (gestational age < .001) in period II-IV, respectively. Simultaneously, cystic periventricular leukomalacia (c-PVL) decreased from 3.3% in period I to 1.3% in period IV (P = .004). Within the total cohort (n = 3287), c-PVL grade III decreased from 2.3% in period I to 0.2% in period IV (P = .003). The number of children with Gross Motor Function Classification System levels III-V decreased from period I to IV (P = .035). Independent risk factors for CP were c-PVL and severe intraventricular hemorrhage, whereas antenatal antibiotics, presence of an arterial line, Caesarean section, and gestational age were independent protective factors. Conclusion: CP incidence and severity decreased from 1990-1993 onward, which could be attributed to a reduction of 93% in severe c-PVL.
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