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Decreasing Incidence and Severity of Cerebral Palsy in Prematurely Born Children

Ingrid C van Haastert, Floris Groenendaal, Cuno S PM Uiterwaal, Jacqueline UM Termote, Marja van der Heide-Jalving, Maria JC Eijsermans, Jan Willem Gorter, Paul JM Helders, Marian J Jongmans, and Linda S de Vries

J Pediatr 159(1):0 (2011) PMID 21367430

Objective: To examine incidence and severity of cerebral palsy (CP), and associated factors among preterm survivors (gestational age < .001) in period II-IV, respectively. Simultaneously, cystic periventricular leukomalacia (c-PVL) decreased from 3.3% in period I to 1.3% in period IV (P = .004). Within the total cohort (n = 3287), c-PVL grade III decreased from 2.3% in period I to 0.2% in period IV (P = .003). The number of children with Gross Motor Function Classification System levels III-V decreased from period I to IV (P = .035). Independent risk factors for CP were c-PVL and severe intraventricular hemorrhage, whereas antenatal antibiotics, presence of an arterial line, Caesarean section, and gestational age were independent protective factors. Conclusion: CP incidence and severity decreased from 1990-1993 onward, which could be attributed to a reduction of 93% in severe c-PVL.

Copyright © 2011 Elsevier Ltd. All rights reserved.

DOI: 10.1016/j.jpeds.2010.12.053
Version: za2963e q8zaf q8zba q8zcb q8zd0 q8ze8 q8zfa q8zg2

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