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Decreasing incidence and severity of cerebral palsy in prematurely born children.

The Journal of Pediatrics 159(1):86 (2011) PMID 21367430

To examine incidence and severity of cerebral palsy (CP), and associated factors among preterm survivors (gestational age <.001) in period II-IV, respectively. Simultaneously, cystic periventricular leukomalacia (c-PVL) decreased from 3.3% in period I to 1.3% in period IV (P=.004). Within the total cohort (n=3287), c-PVL grade III decreased from 2.3% in period I to 0.2% in period IV (P=.003). The number of children with Gross Motor Function Classification System levels III-V decreased from period I to IV (P=.035). Independent risk factors for CP were c-PVL and severe intraventricular hemorrhage, whereas antenatal antibiotics, presence of an arterial line, Caesarean section, and gestational age were independent protective factors. CP incidence and severity decreased from 1990-1993 onward, which could be attributed to a reduction of 93% in severe c-PVL. Copyright © 2011 Mosby, Inc. All rights reserved.

DOI: 10.1016/j.jpeds.2010.12.053