Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.

doi:10.1038/ng.784

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Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.

Heribert H Schunkert, Inke R IR König, Sekar S Kathiresan, Muredach P MP Reilly, Themistocles L TL Assimes, Hilma H Holm, Michael M Preuss, Alexandre F R AF Stewart, Maja M Barbalic, Christian C Gieger, Devin D Absher, Zouhair Z Aherrahrou, Hooman H Allayee, David D Altshuler, Sonia S SS Anand, Karl K Andersen, Jeffrey L JL Anderson, Diego D Ardissino, Stephen G SG Ball, Anthony J AJ Balmforth, Timothy A TA Barnes, Diane M DM Becker, Lewis C LC Becker, Klaus K Berger, Joshua C JC Bis, S Matthijs SM Boekholdt, Eric E Boerwinkle, Peter S PS Braund, Morris J MJ Brown, Mary Susan MS Burnett, Ian I Buysschaert, , John F JF Carlquist, Li L Chen, Sven S Cichon, Veryan V Codd, Robert W RW Davies, George G Dedoussis, Abbas A Dehghan, Serkalem S Demissie, Joseph M JM Devaney, Patrick P Diemert, Ron R Do, Angela A Doering, Sandra S Eifert, Nour Eddine El NE Mokhtari, Stephen G SG Ellis, Roberto R Elosua, James C JC Engert, Stephen E SE Epstein, Ulf U de Faire, Marcus M Fischer, Aaron R AR Folsom, Jennifer J Freyer, Bruna B Gigante, Domenico D Girelli, Solveig S Gretarsdottir, Vilmundur V Gudnason, Jeffrey R JR Gulcher, Eran E Halperin, Naomi N Hammond, Stanley L SL Hazen, Albert A Hofman, Benjamin D BD Horne, Thomas T Illig, Carlos C Iribarren, Gregory T GT Jones, J Wouter JW Jukema, Michael A MA Kaiser, Lee M LM Kaplan, John J P JJ Kastelein, Kay-Tee KT Khaw, Joshua W JW Knowles, Genovefa G Kolovou, Augustine A Kong, Reijo R Laaksonen, Diether D Lambrechts, Karin K Leander, Guillaume G Lettre, Mingyao M Li, Wolfgang W Lieb, Christina C Loley, Andrew J AJ Lotery, Pier M PM Mannucci, Seraya S Maouche, Nicola N Martinelli, Pascal P PP McKeown, Christa C Meisinger, Thomas T Meitinger, Olle O Melander, Pier Angelica PA Merlini, Vincent V Mooser, Thomas T Morgan, Thomas W TW Mühleisen, Joseph B JB Muhlestein, Thomas T Münzel, Kiran K Musunuru, Janja J Nahrstaedt, Christopher P CP Nelson, Markus M MM Nöthen, Oliviero O Olivieri, Riyaz S RS Patel, Chris C CC Patterson, Annette A Peters, Flora F Peyvandi, Liming L Qu, Arshed A AA Quyyumi, Daniel J DJ Rader, Loukianos S LS Rallidis, Catherine C Rice, Frits R FR Rosendaal, Diana D Rubin, Veikko V Salomaa, M Lourdes ML Sampietro, Manj S MS Sandhu, Eric E Schadt, Arne A Schäfer, Arne A Schillert, Stefan S Schreiber, Jürgen J Schrezenmeir, Stephen M SM Schwartz, David S DS Siscovick, Mohan M Sivananthan, Suthesh S Sivapalaratnam, Albert A Smith, Tamara B TB Smith, Jaapjan D JD Snoep, Nicole N Soranzo, John A JA Spertus, Klaus K Stark, Kathy K Stirrups, Monika M Stoll, W H Wilson WH Tang, Stephanie S Tennstedt, Gudmundur G Thorgeirsson, Gudmar G Thorleifsson, Maciej M Tomaszewski, Andre G AG Uitterlinden, Andre M AM van Rij, Benjamin F BF Voight, Nick J NJ Wareham, George A GA Wells, H-Erich HE Wichmann, Philipp S PS Wild, Christina C Willenborg, Jaqueline C M JC Witteman, Benjamin J BJ Wright, Shu S Ye, Tanja T Zeller, Andreas A Ziegler, Francois F Cambien, Alison H AH Goodall, L Adrienne LA Cupples, Thomas T Quertermous, Winfried W März, Christian C Hengstenberg, Stefan S Blankenberg, Willem H WH Ouwehand, Alistair S AS Hall, Panos P Deloukas, John R JR Thompson, Kari K Stefansson, Robert R Roberts, Unnur U Thorsteinsdottir, Christopher J CJ O'Donnell, Ruth R McPherson, Jeanette J Erdmann, and Nilesh J NJ Samani Nat Genet 43(4):333-8 (2011) PMID 21378990 PMCID: PMC3119261

We performed a meta-analysis of 14 genome-wide association studies of coronary artery disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of European descent followed by genotyping of top association signals in 56,682 additional individuals. This analysis identified 13 loci newly associated with CAD at P

DOI: 10.1038/ng.784
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