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Successful treatment of cyclosporine-A-resistant cytophagic histiocytic panniculitis with tacrolimus.

Modern Rheumatology 21(5):553 (2011) PMID 21380742

A 34-year-old woman with discoid lupus erythematosus and lupus profundus was admitted to our hospital showing signs of a fever, malaise, and abdominal swelling. Diagnosis of cytophagic histiocytic panniculitis (CHP) was made based on lobular panniculitis with a hemophagocytosis. Treatment with high doses of prednisolone combined with cyclosporine A (CsA) was not effective enough. However, after changing CsA to tacrolimus (TAC), CHP improved. Our case demonstrates that TAC may be a novel therapy for CHP.

DOI: 10.1007/s10165-011-0435-6