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Isothiocyanates reduce mercury accumulation via an Nrf2-dependent mechanism during exposure of mice to methylmercury.

Takashi T Toyama, Yasuhiro Y Shinkai, Akira A Yasutake, Koji K Uchida, Masayuki M Yamamoto, and Yoshito Y Kumagai

Environ Health Perspect 119(8):1117-22 (2011) PMID 21382770

Methylmercury (MeHg) exhibits neurotoxicity through accumulation in the brain. The transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) plays an important role in reducing the cellular accumulation of MeHg.

DOI: 10.1289/ehp.1003123
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