Advanced search×

One-pot high-yielding synthesis of the DPP4-selective inhibitor ABT-341 by a four-component coupling mediated by a diphenylprolinol silyl ether.

Hayato Ishikawa, Masakazu Honma, and Yujiro Hayashi

Angew Chem Int Ed Engl 50(12):2824-7 (2011) PMID 21387497

DOI: 10.1002/anie.201006204
Version: za2963e q8zab q8zbb q8zc7 q8zd6 q8ze0 q8zf4 q8zgc
Buy PDF

Similar articles you may find interesting…

  1. Click Reaction-Mediated Functionalization of Near-Infrared Pyrrolopyrrole Cyanine Dyes for Biological Imaging Applications.
    Mingzhou Zhou, Xuan Zhang, and Samuel Achilefu

    RSC Adv 3(19):6756-6758 (2013) PMID 23671791

    A clickable pyrrolopyrrole cyanine (PPCy) dye was synthesized by incorporating an alkyne moiety, followed by click reaction with azide-functionalized molecules of different polarities. The clickable dyes are readily amenable to labelling diverse molecules and exhibit an exceptionally...
    Buy PDF
  2. Advances in the understanding of retinal drug disposition and the role of blood-ocular barrier transporters.
    Joaquín Jordán and José M Ruíz-Moreno

    Expert Opin Drug Metab Toxicol (2013) PMID 23647131

    The blood-retinal barrier (BRB) is required for proper vision and controls exchange of nutrients with the choroidal vessels. This barrier serves as a selective partition between the retina and the circulation, and to maintain the specialized environment of the neural retina with a high degree of con...
    Buy PDF
  3. Tricycles by a New Ugi Variation and Pictet-Spengler Reaction in One Pot.
    Mantosh K Sinha, Kareem Khoury, and Alexander Dömling

    Chemistry (2013) PMID 23649922

    Subsequent mild cyclization of aromatic substrates by Pictet-Spengler condensation to stereoselectively gave new tricyclic compounds. Examples are described in decent yield over two steps in one pot, and a crystal structure is also presented to support the proposed structures....
    Buy PDF