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Potential of novel antiretrovirals to modulate expression and function of drug transporters in vitro.

N C L Zembruski, G Buchel, L Jodicke, M Herzog, W E Haefeli, and J Weiss

J Antimicrob Chemother 66(4):802-12 (2011) PMID 21393174

The chemokine receptor antagonists maraviroc and vicriviroc and the integrase inhibitors elvitegravir and raltegravir are novel antiretroviral agents for the treatment of HIV-1 infections. ATP-binding cassette (ABC) transporters as modulators of the effectiveness and safety of therapy can mediate viral resistance and drug-drug interactions. To expand knowledge on drug-drug interactions of these antiretrovirals we investigated whether these compounds are substrates, inhibitors or inducers of important ABC transporters.

DOI: 10.1093/jac/dkq501
Version: za2963e q8zae q8zbd q8zce q8zd6 q8ze9 q8zfa q8zg8

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