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Discovery of novel methanone derivatives acting as antimycobacterial agents.

Mohamed Ashraf MA Ali, Sylvaine S Bastian, Rusli R Ismail, Tan Soo TS Choon, Sadath S Ali, Alexandra A Aubry, Suresh S Pandian, Pankaj P Saraswat, Abhimanyu A Singh, and Ramakant R Gaur

J Enzyme Inhib Med Chem 26(6):890-4 (2011) PMID 21395486

A series of pyrazoline derivatives were synthesized and in vitro activity against Mycobacterium tuberculosis H37Rv was carried out. Among the synthesized compounds, compounds (4d) and (4f) 4-aminophenyl-3-(3,4-dimethoxyphenyl)-6,7-dimethoxy-2,3,3a,4-tetrahydroindeno[1,2-c]pyrazol-2-ylmethanone and 4-aminophenyl-6,7-dimethoxy-3-phenyl-2,3,3a,4-tetrahydroindeno[1,2-c]pyrazol-2-ylmethanone were found to be the most active agent against M. tuberculosis H37Rv with a minimum inhibitory concentration of 10 μg/mL.

DOI: 10.3109/14756366.2011.559945
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