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Effects of early therapeutic administration of interleukin-1beta on survival rate and bone marrow haemopoiesis in irradiated mice.

Alexander A Grebenyuk, Victor V Zatsepin, Natalia N Aksenova, and Alexander A Timoshevsky

Acta Medica (Hradec Kralove) 53(4):221-4 (2010) PMID 21400980

The study was aimed at the experimental assessment of the efficacy of recombinant interleukin-1beta in the early therapy of haemopoiesis disorders caused by X-ray irradiation. The efficacy of the product was based on the 30-day survival rate and average life expectancy of dead animals. Endogenous and exogenous colony-formations were studied to reveal possible mechanisms of therapeutic effects of interleukin-1beta on the bone marrow. The early administration (10-15 min after exposure to radiation) of recombinant interleukin-1beta in a dose of 50 microg/kg increased the survival rate and prevented the post-irradiation decrease in the number of endogenous and exogenous CFU-S9 in irradiated mice.

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