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Management of aromatase inhibitor-associated bone loss in postmenopausal women with breast cancer: practical guidance for prevention and treatment.

P P Hadji, M S MS Aapro, J J JJ Body, N J NJ Bundred, A A Brufsky, R E RE Coleman, M M Gnant, T T Guise, and A A Lipton

Ann Oncol 22(12):2546-55 (2011) PMID 21415233

Bone mineral density (BMD)-based guidelines for bone-directed therapy in women with early breast cancer (EBC) appear inadequate for averting fractures, particularly during aromatase inhibitor (AI) therapy. Therefore, an algorithm was developed to better assess risk and direct treatment (Hadji P, Body JJ, Aapro MS et al. Practical guidance for the management of aromatase inhibitor-associated bone loss. Ann Oncol 2008; 19: 1407-1416). Here, we provide updated guidance on pharmacologic interventions to prevent/treat aromatase inhibitor-associated bone loss (AIBL).

DOI: 10.1093/annonc/mdr017
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