High-density lipoprotein (HDL) is a strong antioxidant, anti-inflammatory, and antisenescence molecule. However, in the current study, HDL from the elderly group (E-HDL) exhibited increased glycation with apolipoprotein (apo) A-I multimerization and decreased phospholipid content. Similarly, glycated apoA-I (gA-I) by fructosylation has a covalently multimerized band without a crosslinker and impaired phospholipid-binding ability. Treatment of human dermal fibroblasts and macrophages with E-HDL and gA-I caused more severe cellular senescence and foam cell formation, respectively; however, treatment with HDL from a young group (Y-HDL) and native apoA-I (nA-I) suppressed senescence and atherosclerosis. E-HDL(3) and reconstituted HDL (rHDL) containing gA-I showed enhanced cholesterol influx into macrophages compared with Y-HDL(3) and nA-I-rHDL. In conclusion, E-HDL and gA-I-rHDL share similar physiologic properties in macrophages and human dermal fibroblasts. E-HDL and gA-I-rHDL exacerbated cellular senescence and atherosclerosis with increased cellular cholesterol influx.
We consider general relativistic homogeneous gravitational collapses for dust
And radiation. We show that replacing the density profile with an effective
Density justified by some quantum gravity framework leads to the avoidance of
The final singularity. The effective density acts on the collapsing...
We have examined resolved stellar photometry from HST imaging surrounding 18
High-mass X-ray binary (HMXB) candidates in NGC 300 and NGC 2403 as determined
From combined Chandra/HST analysis. We have fit the color-magnitude
Distribution of the surrounding stars with stellar evolution models. All but...
We analyze high quality abundances data of solar neighborhood stars and show
That there are two distinct regimes of [alpha/Fe] versus age which we identify
As the epochs of the thick and thin disk formation. A tight correlation between
Metallicity and [alpha/Fe] versus age is clearly identifiable on...
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