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Individual variability in the shape and amplitude of the BOLD-HRF correlates with endogenous GABAergic inhibition.

Suresh D SD Muthukumaraswamy, C John CJ Evans, Richard A E RA Edden, Richard G RG Wise, and Krish D KD Singh

Hum Brain Mapp 33(2):455-65 (2012) PMID 21416560

It has previously been demonstrated that there is a negative correlation between the amplitude of the BOLD response and resting γ amino-butyric acid (GABA) concentration in visual cortex. The work here is the first to empirically characterize individual variability in the haemodynamic response functions (HRFs) in response to a simple visual stimulus and baseline GABA concentration in a population of young adult males (n = 15, aged 20-28 years). The results demonstrate that GABA concentration is negatively correlated with BOLD response amplitude (r = -0.64, P

DOI: 10.1002/hbm.21223
Version: za2963e q8zab q8zbc q8zc4 q8zd1 q8ze7 q8zf7 q8zga
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