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Characterization of the human myocardial proteome in inflammatory dilated cardiomyopathy by label-free quantitative shotgun proteomics of heart biopsies.

Elke E Hammer, Michelle M Goritzka, Sabine S Ameling, Katrin K Darm, Leif L Steil, Karin K Klingel, Christiane C Trimpert, Lars R LR Herda, Marcus M Dörr, Heyo K HK Kroemer, Reinhard R Kandolf, Alexander A Staudt, Stephan B SB Felix, and Uwe U Völker

J Proteome Res 10(5):2161-71 (2011) PMID 21417265

Dilated cardiomyopathy (DCM) is characterized by contractile dysfunction leading to heart failure. The molecular changes in the human heart associated with this disease have so far mostly been addressed at the gene expression level and only a few studies have analyzed global changes in the myocardial proteome. Therefore, our objective was to investigate the changes in the proteome in patients suffering from inflammatory DCM (iDCM) and chronic viral infection by a comprehensive quantitative approach. Comparative proteomic profiling of endomyocardial biopsies (EMB) from 10 patients with iDCM (left ventricular ejection fraction

DOI: 10.1021/pr1008042
Version: za2963e q8zae q8zb5 q8zce q8zdc q8zea q8zf7 q8zg5
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