Advanced search×

Dapsone inhibits IL-8 secretion from human bronchial epithelial cells stimulated with lipopolysaccharide and resolves airway inflammation in the ferret.

Soichiro S Kanoh, Tsuyoshi T Tanabe, and Bruce K BK Rubin

Chest 140(4):980-90 (2011) PMID 21436242

IL-8 is an important activator and chemoattractant for neutrophils that is produced by normal human bronchial epithelial (NHBE) cells through mitogen-activated protein kinase (MAPK) and nuclear factor-κB (NF-κB) p65 pathways. Dapsone, a synthetic sulfone, is widely used to treat chronic neutrophil dermatoses. We investigated the effects of dapsone on polarized IL-8 secretion from lipopolysaccharide (LPS)-stimulated NHBE cells and further evaluated its ability to decrease LPS-induced inflammation in the ferret airway.

DOI: 10.1378/chest.10-2908
Version: za2963e q8za6 q8zb4 q8zc5 q8zd4 q8ze0 q8zfb q8zga

Similar articles you may find interesting…

  1. Bench-to-bedside review: endotoxin tolerance as a model of leukocyte reprogramming in sepsis.
    Jean-Marc Cavaillon and Minou Adib-Conquy

    Crit Care 10(5):233 (2006) PMID 17044947 PMCID 1751079

    Endotoxin tolerance is defined as a reduced responsiveness to a lipopolysaccharide (LPS) challenge following a first encounter with endotoxin. Endotoxin tolerance protects against a lethal challenge of LPS and prevents infection and ischemia-reperfusion damage. Endotoxin tolerance is paralleled by a...
    View PDF
  2. Endotoxin tolerance: A review.
    Michael A. West and Wyrta Heagy

    Crit Care Med 30(1 Supp):S64-S73 (2002) PMID 11891406

    Endotoxin tolerance was initially described when it was observed that animals survived a lethal dose of bacterial endotoxin if they had been previously treated with a sublethal injection. In animal models, two phases of endotoxin tolerance are described, an early phase associated wit...
  3. The danger within: endogenous danger signals, atopy and asthma.
    M A M Willart and B N Lambrecht

    Clin Exp Allergy 39(1):12-9 (2009) PMID 19016800

    In allergic asthmatics, airway inflammation is triggered by specific (inhalation of allergen such as house dust mite allergen and pollen spores) or non-specific triggers (such as air pollutants and viral infection). Most of these inhaled particles are immunologically inert. Dendritic cells (DCs) are...