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Renin-Angiotensin-aldosterone system in diabetes and hypertension.

Willa A Hsueh and Kathleen Wyne

J Clin Hypertens (Greenwich) 13(4):224-37 (2011) PMID 21466617

Activation of the renin-angiotensin-aldosterone system (RAAS) is the primary etiologic event in the development of hypertension in people with diabetes mellitus. Modulation of the RAAS has been shown to slow the progression and even cause regression of the microvascular and macrovascular complications associated with diabetes mellitus. Early pharmacotherapy with agents that decrease RAAS activation in the adipose tissue have had a dramatic impact on the prevalence of diabetes related complications. Recent data show that preventing the development of "angry fat" can prevent not just hypertension but also type 2 diabetes mellitus and its associated complications. This review updates what is known about angry fat and the role of RAAS inhibition in preventing the metabolic sequelae of local RAAS activation. © 2011 Wiley Periodicals, Inc.

DOI: 10.1111/j.1751-7176.2011.00449.x
Version: za2963e q8za2 q8zb8 q8zcc q8zdd q8zea q8zf8 q8zg1

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