Advanced search×

Keratin 23, a novel DPC4/Smad4 target gene which binds 14-3-3ε

Sven-T Liffers, Abdelouahid Maghnouj, Johanna B Munding, René Jackstadt, Ulrike Herbrand, Thomas Schulenborg, Katrin Marcus, Susanne Klein-Scory, Wolff Schmiegel, Irmgard Schwarte-Waldhoff, Helmut E Meyer, Kai Stühler, and Stephan A Hahn

BMC Cancer 11(1):137 (2011) PMID 21492476

Inactivating mutations of SMAD4 are frequent in metastatic colorectal carcinomas. In previous analyses, we were able to show that restoration of Smad4 expression in Smad4-deficient SW480 human colon carcinoma cells was adequate to suppress tumorigenicity and invasive potential, whereas in vitro cell growth was not affected. Using this cellular model system, we searched for new Smad4 targets comparing nuclear subproteomes derived from Smad4 re-expressing and Smad4 negative SW480 cells.

DOI: 10.1186/1471-2407-11-137
Version: za2963e q8za8 q8zba q8zce q8zd7 q8ze7 q8zf9 q8zg1
PDF not found

Similar articles you may find interesting…

  1. Enteric glia promote intestinal mucosal healing via activation of focal adhesion kinase and release of proEGF.
    Laurianne L Van Landeghem, Julien J Chevalier, ... Michel M Neunlist

    Am J Physiol Gastrointest Liver Physiol 300(6):G976-87 (2011) PMID 21350188 PMCID PMC3119120

    Our study shows that enteric glia represent a functionally important cellular component of the intestinal epithelial barrier microenvironment and that the disruption of this cellular network attenuates the mucosal healing process....
    View PDF
  2. Medical interventions for high grade vulval intraepithelial neoplasia.
    Litha Pepas, Sonali Kaushik, ... Heather O Dickinson

    Cochrane Database Syst Rev (2011) PMID 21491403

    We searched the Cochrane Gynaecological Cancer Group Trials Register, Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2010, Issue 3), MEDLINE and EMBASE (up to September 2010). We also searched registers of clinical trials, abstracts of scientific meetings, reference l...
  3. Medical interventions for high grade vulval intraepithelial neoplasia.
    Litha L Pepas, Sonali S Kaushik, ... Heather O HO Dickinson

    Cochrane Database Syst Rev (2011) PMID 21491403

    Imiquimod appears to be effective, but its safety needs further examination. Its use is associated with side effects which are tolerable, but more extensive data on adverse effects are required. Long term follow-up should be mandatory in view of the known progression of high grade VIN to invasive di...