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Regulation of mammalian target of rapamycin complex 1 (mTORC1) by hypoxia: causes and consequences.

Hakan Cam and Peter J Houghton

Target Oncol 6(2):95-102 (2011) PMID 21499767

Integration of cellular and extracellular signals maintains tissue homeostasis under conditions of normal proliferation and stress. A central player in regulating responses to stress is the serine/threonine kinase mammalian target of rapamycin (mTOR). In many cancers, mTOR complex 1 (mTORC1) signaling is enhanced, even under conditions where such signaling should be suppressed. This article reviews some of the details that are emerging on how low oxygen (hypoxia) regulates mTORC1 signaling, and the consequences for dysregulation in pediatric solid tumors.

DOI: 10.1007/s11523-011-0173-x
Version: za2963e q8zad q8zb6 q8zc8 q8zdf q8zea q8zf8 q8zg1
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