A major goal of the worldwide malaria eradication program is the reduction and eventual elimination of malaria transmission. All currently available antimalarial compounds were discovered on the basis of their activity against the asexually reproducing red blood cell stages of the parasite, which are responsible for the morbidity and mortality of human malaria. Resistance against these compounds is widespread, and there is an urgent need for novel approaches to reduce the emergence of resistance to new antimalarials as they are introduced. We have established and validated the first high-throughput assay targeting the red blood cell parasite stage required for transmission, the sexually reproducing gametocyte. This assay will permit identification of compounds specifically targeting the transmission stages in addition to the asexual stage parasites. Such stage-specific compounds may be used in a combination therapy, reducing the emergence of resistance by blocking transmission of resistant parasites that may be selected in a patient.
We give conditions for the existence and minimality of a single
Test case chain and minimise the number of test chains if a single test chain
Is infeasible. We report experimental results with a prototype tool for C code
Generated from Simulink models and compare it to state-of-the-art test suite
We have applied the induced-activation method
In off-line analysis. A total of 115 isotopes of all elements in the range $7
\leq A \leq 69$ were unambiguously identified with high precision. There is a
Consideration that the formed nuclides could be produced in a very asymmetric
Binary decay of heav...
We have used the Australia Telescope Compact Array to undertake the first
High-resolution observations of the 19.9-GHz methanol maser transition. The
Emission is coincident with the location of the targeted 6.7-GHz methanol
Masers to within 0.2 arcseconds in absolute position. We find that the relat...
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