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Genetic predictors of fibrin D-dimer levels in healthy adults.

Nicholas L NL Smith, Jennifer E JE Huffman, David P DP Strachan, Jie J Huang, Abbas A Dehghan, Stella S Trompet, Lorna M LM Lopez, So-Youn SY Shin, Jens J Baumert, Veronique V Vitart, Joshua C JC Bis, Sarah H SH Wild, Ann A Rumley, Qiong Q Yang, Andre G AG Uitterlinden, David J DJ Stott, Gail G Davies, Angela M AM Carter, Barbara B Thorand, Ozren O Polašek, Barbara B McKnight, Harry H Campbell, Alicja R AR Rudnicka, Ming-Huei MH Chen, Brendan M BM Buckley, Sarah E SE Harris, Annette A Peters, Drazen D Pulanic, Thomas T Lumley, Anton J M AJ de Craen, David C DC Liewald, Christian C Gieger, Susan S Campbell, Ian I Ford, Alan J AJ Gow, Michelle M Luciano, David J DJ Porteous, Xiuqing X Guo, Naveed N Sattar, Albert A Tenesa, Mary M Cushman, P Eline PE Slagboom, Peter M PM Visscher, Tim D TD Spector, Thomas T Illig, Igor I Rudan, Edwin G EG Bovill, Alan F AF Wright, Wendy L WL McArdle, Geoffrey G Tofler, Albert A Hofman, Rudi G J RG Westendorp, John M JM Starr, Peter J PJ Grant, Mahir M Karakas, Nicholas D ND Hastie, Bruce M BM Psaty, James F JF Wilson, Gordon D O GD Lowe, Christopher J CJ O'Donnell, Jacqueline C M JC Witteman, J Wouter JW Jukema, Ian J IJ Deary, Nicole N Soranzo, Wolfgang W Koenig, and Caroline C Hayward

Circulation 123(17):1864-72 (2011) PMID 21502573 PMCID PMC3095913

Fibrin fragment D-dimer, one of several peptides produced when crosslinked fibrin is degraded by plasmin, is the most widely used clinical marker of activated blood coagulation. To identity genetic loci influencing D-dimer levels, we performed the first large-scale, genome-wide association search.

DOI: 10.1161/CIRCULATIONAHA.110.009480
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